The concomitant use of METHADOSE with all cytochrome P450 3A4, 2B6, 2C19, 2C9 or 2D6 inhibitors may well result in an increase in methadone plasma concentrations, which could induce probably fatal respiratory melancholy. On top of that, discontinuation of concomitantly utilized cytochrome P450 3A4, 2B6, 2C19, or 2C9 inducers may bring about an incr